All kick-off times in GMT.
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- Wed, May 22, 2013
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| 22:45 | Real Garcilaso | v | Independiente Santa Fe |
| May 23, 01:00 | Fluminense FC | v | Olimpia |
| Postp | Rubio Ñú | P - P | Olimpia |
| 19:00 | Nacional | v | Deportivo Capiatá |
| 19:00 | Sol de América | v | General Díaz |
| 19:00 | Sp. Carapeguá | v | Cerro Porteño de Franco |
| 22:00 | Guaraní | v | Sportivo Luqueño |
| 22:20 | Cerro Porteño | v | Libertad |