All kick-off times in GMT.
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- Sat, May 19, 2012
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| FT | Almeria | 2 - 0 | AD Alcorcon |
| FT | Celta Vigo | 4 - 0 | Alcoyano |
| FT | Elche | 2 - 3 | Guadalajara |
| FT | Girona | 3 - 1 | Cordoba |
| FT | Huesca | 1 - 0 | FC Cartagena |
| FT | Las Palmas | 2 - 0 | Hercules |
| FT | Villarreal B | 2 - 0 | Recreativo Huelva |
| FT | Banfield | 0 - 3 | Estudiantes La Plata |
| FT | All Boys | 1 - 0 | San Martín de San Juan |
| FT | Unión de Santa Fe | 1 - 0 | San Lorenzo |
| FT | Cobreloa | 1 - 2 | Unión Española |
| FT | Municipal Iquique | 4 - 1 | Unión San Felipe |
| FT | Palestino | 1 - 0 | La Serena |
| FT | Audax Italiano | 1 - 3 | Colo Colo |
| FT | Cerrito | 1 - 2 | Wanderers |
| FT | Cerro | 1 - 2 | Danubio F.C. |
| FT | Liverpool | 5 - 4 | Fénix |
| FT | Rentistas | 0 - 3 | Rampla Juniors |
| FT | River Plate | 4 - 0 | El Tanque Sisley |
| FT | La Equidad | 1 - 1 | Real Cartagena |
| FT | Patriotas F.C. | 0 - 0 | Boyacá Chicó FC |
| FT | Deportivo Pasto | 1 - 1 | Deportes Tolima |
| FT | Independiente Santa Fe | 1 - 0 | Itagüí |
| FT | Unión Comercio | 2 - 0 | San Martin |
| FT | Sporting Cristal | 4 - 0 | José Gálvez |
| FT | Club Sportivo Cienciano | 0 - 1 | Juan Aurich |
| FT | César Vallejo | 2 - 1 | Real Garcilaso |
| FT | Omiya Ardija | 0 - 2 | Kawasaki Frontale |
| FT | Kashima Antlers | 7 - 0 | Consadole Sapporo |
| FT | Vegalta Sendai | 4 - 0 | Nagoya Grampus Eight |
| FT | Cerezo Osaka | 1 - 2 | Kashiwa Reysol |
| FT | FC Tokyo | 3 - 2 | Sagan Tosu |
| FT | Bristol Academy Women's FC | 3 - 2 | Doncaster Rovers Belles |