All kick-off times in GMT.
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- Sun, Dec 2, 2012
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| FT | Granada | 0 - 0 | Espanyol |
| FT | Deportivo La Coruña | 2 - 3 | Real Betis |
| FT | Celta Vigo | 1 - 1 | Levante |
| FT | Mallorca | 1 - 1 | Real Zaragoza |
| FT | Racing Santander | 3 - 4 | Almeria |
| FT | Recreativo Huelva | 0 - 2 | Ponferradina |
| FT | AD Alcorcon | 4 - 1 | Girona |
| FT | Huesca | 1 - 1 | Hercules |
| FT | Mirandes | 0 - 0 | Guadalajara |
| FT | Numancia | 2 - 1 | CD Sabadell |
| FT | Elche | 1 - 0 | Villarreal |
| FT | Napoli | 5 - 1 | US Pescara |
| FT | Bologna | 2 - 1 | Atalanta |
| FT | Genoa | 2 - 4 | Chievo Verona |
| FT | Internazionale | 1 - 0 | Palermo |
| FT | Lazio | 2 - 1 | Parma |
| FT | Siena | 1 - 3 | AS Roma |
| FT | Udinese | 4 - 1 | Cagliari |
| FT | Fiorentina | 2 - 2 | Sampdoria |
| FT | FC Cologne | 1 - 0 | FC Ingolstadt 04 |
| FT | FSV Frankfurt | 1 - 2 | TSV Eintracht Braunschweig |
| FT | SC Paderborn 07 | 0 - 2 | MSV Duisburg |
| FT | NEC Nijmegen | 1 - 1 | NAC Breda |
| FT | FC Groningen | 2 - 0 | SC Heracles Almelo |
| FT | FC Utrecht | 2 - 1 | AZ Alkmaar |
| FT | Vitesse Arnhem | 3 - 0 | Roda JC Kerkrade |
| FT | Istanbul Buyuksehir BSK | 2 - 0 | Sivasspor |
| FT | Antalyaspor | 1 - 0 | Mersin Idmanyurdu |
| FT | Eskisehirspor K | 2 - 2 | Kasimpasa |
| FT | Kayserispor | 1 - 1 | Fenerbahce |
| FT | OFI Crete | 1 - 1 | Panthrakikos |
| FT | Levadiakos | 2 - 0 | Kerkyra |
| FT | Veria | 0 - 0 | PAOK Salonika |
| FT | Panionios | 1 - 2 | Panathinaikos |
| FT | KSC Lokeren | 3 - 4 | Racing Genk |
| FT | Waasland-Beveren | 0 - 2 | Standard Liege |
| FT | Belgrano de Córdoba | 1 - 0 | Tigre |
| FT | River Plate | 1 - 0 | Lanús |
| FT | Vélez Sarsfield | 2 - 0 | Unión de Santa Fe |
| FT | San Lorenzo | 2 - 1 | Independiente |
| FT | Arsenal de Sarandí | 1 - 0 | Boca Juniors |
| FT | Central Español | 2 - 5 | River Plate |
| FT | Danubio F.C. | 2 - 1 | Fénix |
| FT | Liverpool | 4 - 4 | Racing (U) |
| FT | Peñarol | 2 - 0 | Juventud |
| Group A | |||
|---|---|---|---|
| FT | Atlético Junior | 1 - 1 | Deportes Tolima |
| FT | Millonarios | 1 - 0 | Deportivo Pasto |
| Group B | |||
| FT | Independiente Medellín | 1 - 0 | La Equidad |
| FT | Real Garcilaso | 0 - 1 | Sporting Cristal |
| FT | Sol de América | 1 - 1 | Guaraní |
| FT | Sp. Carapeguá | 0 - 4 | Tacuary |
| FT | Olimpia | 0 - 0 | Cerro Porteño de Franco |
| FT | Barcelona | 3 - 1 | Olmedo |
| FT | Club Deportivo Cuenca | 1 - 0 | Emelec |
| FT | Deportivo Quito | 0 - 4 | Macará |
| FT | LDU Quito | 1 - 0 | Manta F.C. |
| FT | Liga de Loja | 2 - 1 | Independiente Terán |
| FT | Tec. Universitario | 1 - 3 | El Nacional |
| FT | Atlético Venezuela | 1 - 1 | Dep. Petare |
| FT | Atlético Vigía | 1 - 0 | Yaracuyanos |
| FT | Portuguesa | 0 - 2 | A.C. Mineros |
| FT | Zulia | 1 - 2 | Llaneros |
| FT | Anzoátegui | 1 - 0 | Real Espor |
| FT | Caracas F.C. | 2 - 1 | Monagas SC |
| FT | CD Lara | 0 - 0 | Deportivo Táchira |
| FT | Aragua | 3 - 3 | Estudiantes de Mérida |
| FT | Zamora | 5 - 2 | Trujillanos |
| FT | Victoria | 2 - 2 | CD Motagua |
| FT | Olimpia | 2 - 0 | Atletico Choloma |