All kick-off times in GMT.
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- Wed, Dec 5, 2012
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| FT | Gimnasia (CDU) | (4)0 - 0(3) | Ben Hur |
| FT | Santamarina | 2 - 0 | Def. de Belgrano (VR) |
| FT | Brown (Posadas) | 3 - 0 | Dep. Mandiyú |
| FT | Central Norte | 1 - 0 | Gimnasia y Tiro (Orán) |
| FT | San Martín de Tucumán | 3 - 1 | San Jorge (Tucumán) |
| FT | Sp. Belgrano | 2 - 1 | Sp. Atenas |
| FT | Talleres de Córdoba | 3 - 0 | Racing (Cba) |
| FT | At. Unión (SJ) | 2 - 1 | San Martín (M) |
| FT | Guillermo Brown | 1 - 0 | Boca (Río Gallegos) |
| FT | Estudiantes de Buenos Aires | 2 - 0 | Riestra |