All kick-off times in GMT.
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- Fri, Dec 21, 2012
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| FT | Arles | 1 - 1 | Dijon FCO |
| FT | Caen | 1 - 0 | Chateauroux |
| FT | Clermont Foot | 1 - 2 | AJ Auxerre |
| FT | FC Istres | 2 - 2 | Lens |
| FT | Guingamp | 0 - 0 | Ajaccio GFCO |
| FT | Nimes | 3 - 1 | Niort |
| FT | Stade Laval | 1 - 2 | Le Havre AC |
| FT | Tours | 1 - 2 | Angers |
| FT | Akhisar Belediye | 0 - 0 | Orduspor |
| FT | Besiktas | 3 - 1 | Kayserispor |