All kick-off times in GMT.
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- Thu, Feb 14, 2013
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| Group 2 | |||
|---|---|---|---|
| FT | Palmeiras | 2 - 1 | Sporting Cristal |
| Group 3 | |||
| FT | The Strongest | 2 - 1 | Arsenal de Sarandí |
| Group 6 | |||
| FT | Deportes Tolima | 2 - 1 | Cerro Porteño |
| Group 7 | |||
| FT | Newell's Old Boys | 3 - 1 | Olimpia |
| Group 8 | |||
| FT | Gremio | 1 - 2 | Huachipato |
| FT | Belen | 1 - 1 | Club Sport Uruguay |
| FT | Carmelita | 0 - 1 | Perez Zeledon |
| FT | CD Motagua | 1 - 0 | Atletico Choloma |