All kick-off times in GMT.
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- Fri, Feb 22, 2013
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| FT | AJ Auxerre | 2 - 1 | Guingamp |
| FT | Angers | 1 - 0 | Ajaccio GFCO |
| FT | Caen | 2 - 1 | Stade Laval |
| FT | Chateauroux | 2 - 0 | Arles |
| FT | Clermont Foot | 0 - 0 | Dijon FCO |
| FT | Nimes | 1 - 0 | FC Istres |
| FT | Niort | 2 - 3 | Le Mans |
| FT | Sedan | 1 - 1 | Tours |
| FT | Mogi Mirim EC | 1 - 0 | Oeste |
| FT | Paulista FC | 3 - 1 | Atlético Sorocaba |
| FT | Atletico Choloma | 3 - 1 | Deportes Savio |